Biomolecular Interactions

The MOBILIsE Advanced Training Course in Molecular Bioengineering is designed to provide a training platform for educating the next generation of Molecular Bioengineering leaders – a rapidly growing field that explores the most recent advances in chemical, biological, and engineering sciences, to develop advanced molecular-level solutions to complex medical problems. This year, on its 4th edition, the course will be organised together with the SNOOPY COST Action (CA23111), and will focus on the power of peptides in therapeutics and cosmetic development, aiming to provide an integrated view of skin-active peptides, spanning cosmetic peptide discovery and design, advanced characterization, formulation, and translational therapeutic applications

As in the previous editions, the course will run the entire day from Monday to Friday. The program combines morning lectures with hands-on practical sessions (26 hours total) in the afternoons, enabling participants to connect theory with real-world experimental workflows. In this edition, participants will:

> Gain a solid understanding of peptide roles in skin care and therapeutics;
> Acquire hands-on experience with key characterization and modelling techniques;
> Learn how to translate cosmetic peptide research toward therapeutic applications;
> Develop skills in data analysis, reporting, and scientific communication; and
> Gain industry perspectives highlighting translational and formulation perspectives.

The Advanced Training Course in Molecular Bioengineering is designed to provide a training platform for educating the next generation of leaders in Molecular Bioengineering, a rapidly growing field that explores the most recent advances in chemical, biological, and engineering sciences to develop advanced molecular-level solutions to complex medical problems. This year, on its 3rd edition, the course focuses on “Biomolecular Interactions Modelling: in silico and experimental approaches for molecular self-assembly and Medicine”.

Peptides and proteins mediate many physiological and bioengineering-relevant phenomena, playing a crucial role in drug design and discovery, whether as therapeutic or delivery agents. Also, peptide epitopes play a key role in driving communication between cells and their extracellular matrix, offering opportunities for controlling cell adhesion, differentiation, immunomodulation and matrix turnover. A deeper understanding behind the biophysical interactions responsible for these functions offers the possibility to improve biomolecular affinity and biomaterials’ fabrication reproducibility, which can lead to the fabrication of high-precision biological scaffolds, smart/functional medical devices, sustainable nanoelectronics and biosensors.

This Course will cover the fundamentals of biophysical techniques relevant for the in silico and experimental assessment of molecular interactions, including three-dimensional structure, self-assembling capability and solubility predictions of peptides and proteins, being relevant for a range of biomedical applications, such as drug discovery, biosensing, functional biomaterials design, tissue engineering, among others.